About Us
Commitment to Innovation
Allvivo is a biomedical company committed to the development of improved antimicrobial technologies to reduce medical device and wound related infections. With facilities in Lake Forest, California, Allvivo collaborates with licensees and marketing partners to deliver safe and effective treatment options that simplify infection control, improve patient outcomes, and improve healthcare economics.
Core competencies in coating, drug delivery and alternative antimicrobials.
Technology
Allvivo develops coatings for medical devices and combination products. We specialize in the development of antimicrobial technologies that are based on the combination of novel engineered antimicrobial peptides with biocompatible delivery formulations that prevent biofilms from establishing on medical device and tissue surfaces.
Antimicrobial Peptides
Inspired by natural antimicrobial peptides, Allvivo’s lead peptides, ASP-1 and ASP-2, have been engineered to increase specificity for bacterial pathogens versus host cells, potency, and stability to enable high level performance within a range of harsh physiologic environments. Key distinguishing features of our peptides include their ability to eradicate bacteria within biofilms and their ability to kill pathogens rapidly by membrane disruption, reducing potential for development of resistance.
Formulation Technology
Allvivo produces durable antimicrobial formulations for medical devices and multiple formats for wound treatment including biodegradable formulations. When combined with our formulation technology, the ASP peptides withstand challenging manufacturing environments, are compatible with end stage sterilization, and maintain good shelf stability. The biocompatible nature of our formulations provides an environment conducive to healing and prevents fouling of device surfaces to improve device performance and longevity.
Technology Advantages
- Broad spectrum antimicrobial protection
- Effective at preventing biofilm formation and eradicating preformed biofilms
- Effective against multidrug resistant bacteria
- Significantly more biocompatible than silver and antiseptic technologies
- Excellent stability
- Release profiles tailored to device requirements
- Formulations protect peptides and retain activity in the presence of serum and wound exudate
- Active over a broad pH range
